204331-79-3Relevant academic research and scientific papers
Fe(III)-Catalyzed Aerobic Intramolecular N-N Coupling of Aliphatic Azides with Amines
Zhang, Yue,Duan, Dongyu,Zhong, Ying,Guo, Xin-Ai,Guo, Jiawei,Gou, Jing,Gao, Ziwei,Yu, Binxun
supporting information, p. 4960 - 4965 (2019/09/03)
An Fe(III)-catalyzed intramolecular N-N coupling of aliphatic azidoamines that forms diverse five- and six-membered semisaturated diazoheterocycles using air as an oxidant is reported, providing an alternative to hydrazine-based methods. Mechanistic studies suggest that a N-radical induced intramolecular homolytic substitution (SH2) is involved in ring closure. The power of this N-N bond-forming method is also demonstrated by using it as the final step in a total synthesis of (-)-newbouldine.
Synthesis method of natural product (-)-newbouldine
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, (2019/07/16)
The invention discloses a synthesis method of a natural product (-)-newbolline. With optically-active Boc protected pyrrolidine formamide as a raw material, five chemical conversion processes are successively carried out, namely, a Grignard reaction, a Wi
Total synthesis of newbouldine via reductive N-N bond formation
Pangerl, Michael,Hughes, Chambers C.,Trauner, Dirk
experimental part, p. 6626 - 6631 (2010/10/19)
The first total synthesis of newbouldine has been achieved employing a new, reductive N-N bond forming reaction. The asymmetric synthesis confirms that the natural product is a racemate.
