204377-88-8

Basic information

• Product Name: 8-Bromo-4-chromanone
• Synonyms: 8-Bromo-4-chromanone;8-bromo-chroman-4-one;8-Bromo-2,3-dihydro-4H-1-benzopyran-4-one;8-broMo-3,4-dihydro-2H-1-benzopyran-4-one;8-BroMo-4-chroManone 97%;8-broMo-2,3-dihydrochroMen-4-one;8-bromo-2,3-dihydro-4H-chromen-4-one
• CAS NO: 204377-88-8
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.05468
• EINECS: 1312995-182-4
• Mol File: 204377-88-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 339℃
• Flash Point: 159℃
• Appearance: /
• Density: 1.621
• Vapor Pressure: 9.21E-05mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-Bromo-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Bromo-4-chromanone(204377-88-8)
• EPA Substance Registry System: 8-Bromo-4-chromanone(204377-88-8)

Safety Data

• Hazardous Substances Data: 204377-88-8(Hazardous Substances Data)

Usage

General Description

8-Bromo-4-chromanone, also known as 8-Bromo-4H-chromen-4-one, is a chemical compound with a molecular formula C9H5BrO2. It is a derivative of chromanone, a type of organic compound with a heterocyclic ring structure. 8-Bromo-4-chromanone is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical products. It exhibits potential biological activities, such as antioxidant, anti-inflammatory, and anticancer properties. Due to these properties, it has attracted attention in the field of medicinal chemistry as a potential lead compound for the development of new drugs. Additionally, 8-Bromo-4-chromanone has been studied for its potential applications in the field of organic electronics, specifically as a material for organic photovoltaic devices.

InChI:InChI=1/C9H7BrO2/c10-7-3-1-2-6-8(11)4-5-12-9(6)7/h1-3H,4-5H2

Upstream product

• 1403387-58-5 1-bromo-2-((3-chloroprop-2-yn-1-yl)oxy)benzene 
• 38770-76-2 1-bromo-2-(prop-2-yn-1-yloxy)benzene 
• 165538-35-2 3-(2-bromophenoxy)propionic acid 
• 95-56-7 2-hydroxybromobenzene 
• 154405-38-6 3-(2-bromophenoxy)propionitrile 

Downstream Products

• 1260485-22-0 8-bromo-4H-chromen-4-one 
• 1260485-25-3 (E)-8-styrylchromone 
• 3722-78-9 8-bromo-3,4-dihydro-2H-1-benzopyran 

Relevant articles and documents

Design, synthesis and biological evaluation of novel benzopyran sulfonamide derivatives as 5-HT6 receptor ligands

On the basis of a known pharmacophore model for 5-HT6 receptor antagonists (5-HT6R), we have designed and synthesized a novel series of benzopyran sulfonamide derivatives 9(a-d), 20(a-d) and 21(a-d) and their structures were confirmed by 1H NMR and mass spectral data. All the synthesized compounds were tested for their antagonistic activity towards 5-HT6R in a cell based reporter gene in vitro functional assay. Most of the tested compounds showed moderate to potent binding affinities towards 5-HT6R.

Efficient synthesis of chromones with alkenyl functionalities by the heck reaction

The usefulness of the Heck reaction in the field of chromones has been demonstrated. Bromochromones with the halogen atom in their rings A and B were reacted with various terminal alkenes to give hitherto unknown alkenyl-substituted chromones. Reactivity of the substrates was found to markedly depend on the position of the bromine atom. Under phosphine-free conditions using a phase-transfer catalyst additive (tetrabutylammonium bromide), shorter reaction periods and usually higher yields were obtained.