204381-62-4

Basic information

• Product Name: N-[N-(quinolin-2-ylcarbonyl)-L-phenylalanyl]pyrrolidin-3-one
• Synonyms: N-[N-(quinolin-2-ylcarbonyl)-L-phenylalanyl]pyrrolidin-3-one
• CAS NO: 204381-62-4
• Molecular Weight: 387.438
• Mol File: 204381-62-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[N-(quinolin-2-ylcarbonyl)-L-phenylalanyl]pyrrolidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: N-[N-(quinolin-2-ylcarbonyl)-L-phenylalanyl]pyrrolidin-3-one(204381-62-4)
• EPA Substance Registry System: N-[N-(quinolin-2-ylcarbonyl)-L-phenylalanyl]pyrrolidin-3-one(204381-62-4)

Safety Data

• Hazardous Substances Data: 204381-62-4(Hazardous Substances Data)

Upstream product

• 204381-53-3 Benzoic acid 1-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidin-3-yl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 186431-54-9 1-[(tert-butoxycarbonyl)-L-phenylalanyl]-3(R,S)-pyrrolidinol 
• 186431-53-8 N-[N-(tert-butoxycarbonyl)-L-phenylalanyl]pyrrolidin-3-one 
• 93-10-7 quinoline-2-carboxylic acid 
• 50342-01-3 quinolin-2-ylcarbonyl chloride 
• 204381-60-2 1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-3-one 

Relevant articles and documents

Parallel synthesis of new phenylalanino-2-(phenylthio)pyrrolidin-3-one scaffold-based analogues

Based on the specific PhePro proteolytic cleavage of the HIV-protease, we synthesized short pseudopeptides incorporating a 2-(phenylthio)pyrrolidin-3-one ring. We previously described various analogues based on this scaffold. We report herein a parallel m

Short and unexpectedly potent 3-pyrrolidinone type inhibitors of HIV-1 replication

Based on the specific PhePro proteolytic cleavage of the HIV protease, short pseudo-peptides incorporating a 3-pyrrolidinone none ring have been synthesized. Their potencies to inhibit HIV-1 in MT4 cell culture have been evaluated and compared to that of the bioisostere dipeptide BocPhePro. Analogues incorporating an aromatic residue have shown to inhibit HIV-1 infection in MT4 human lymphoid cell with an IC50 ranging from 1 to 10 μM. Further experiments are in progress to determine their HIV protease inhibition properties.