204397-68-2

Upstream product

• 214463-38-4 (E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 
• 204397-62-6 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-methyl-7-oxo-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] 
• 186256-68-8 cryptophycin 53 
• 186256-66-6 cryptophycin-51 
• 204397-65-9 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-[4-[[[tris(1-methylethyl)silyl]oxy]methyl]phenyl]-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl] 

Downstream Products

• 204398-47-0 pentanoic acid, 3-chloro-N-[(2E,6S,7R,8S)-8-chloro-8-[4-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]methyl]phenyl]-5,7-dihydroxy-6-methyl-1-oxo-2-octenyl]-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl-, (3->1⁵)-lactone, (2S)- 
• 204398-46-9 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-6-[(2R,3R)-3-[4-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]methyl]phenyl]oxiranyl]-5-hydroxy-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] 
• 204397-74-0 tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester 
• 204397-72-8 tert-Butoxycarbonylamino-acetic acid 4-((2R,3R)-3-{(S)-1-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-ethyl}-oxiranyl)-benzyl ester 
• 204398-49-2 pentanoic acid, 3-chloro-N-[(2E,5S,6S)-6-[(2R,3R)-3-[4-[[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]amino]methyl]phenyl]oxiranyl]-5-hydroxy-1-oxo-2-heptenyl]-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl-. (3->1⁵)-lactone, (2S)- 
• 204398-44-7 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-6-[(2R,3R)-3-[4-[(diethylamino)methyl]phenyl]oxiranyl]-5-hydroxy-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] 
• 204398-14-1 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-6-[(2R,3R)-3-[4-(chloromethyl)phenyl]oxiranyl]-5-hydroxy-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] 
• 204397-70-6 pentanoic acid, 3-chloro-N-[(2E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-[4-(hydroxymethyl)phenyl]oxiranyl]-1-oxo-2-heptenyl]-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl-, (3->1⁵)-lactone, (2S)- 

Relevant academic research and scientific papers

A convergent approach to cryptophycin 52 analogues: Synthesis and biological evaluation of a novel series of fragment A epoxides and chlorohydrins

Cryptophycin 52 is a synthetic derivative of Cryptophycin 1, a potent antimicrotubule agent isolated from cyanobacteria. In an effort to increase the potency and water solubility of the molecule, a structure-activity relationship study (SAR) was initiated