204397-92-2

Upstream product

• 204397-62-6 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-methyl-7-oxo-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] 
• 186256-66-6 cryptophycin-51 
• 186256-68-8 cryptophycin 53 
• 214463-38-4 (E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 

Downstream Products

• 204397-96-6 3-tert-Butoxycarbonylamino-2,2-dimethyl-propionic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-phenyl ester 
• 204397-95-5 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-8-[4-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethyl-1-oxopropoxy]phenyl]-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl] 
• 204397-94-4 pentanoic acid, 3-chloro-N-[(2E,5S,6R,7E)-5-hydroxy-8-(4-hydroxyphenyl)-6-methyl-1-oxo-2,7-octadienyl]-O-methyl-D-tyrosyl-2,2-dimethyl-β-alanyl-2-hydroxy-4-methyl, (3->1⁵)-lactone, (2S)- 

Relevant academic research and scientific papers

Cryptophycin compounds

The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.

A convergent approach to cryptophycin 52 analogues: Synthesis and biological evaluation of a novel series of fragment A epoxides and chlorohydrins

Cryptophycin 52 is a synthetic derivative of Cryptophycin 1, a potent antimicrotubule agent isolated from cyanobacteria. In an effort to increase the potency and water solubility of the molecule, a structure-activity relationship study (SAR) was initiated