204398-86-7Relevant academic research and scientific papers
Synthetic studies toward astins A, B and C. Efficient syntheses of cis- 3,4-dihydroxyprolines and (-)-(3S,4R)-dichloroproline esters
Schumacher, Kelly K.,Jiang, Jianjun,Joullie, Madeleine M.
, p. 47 - 53 (1998)
Efficient syntheses of the esters of cis-3,4-dihydroxyprolines and the first synthesis of the ester of the rare amino acid (-)-(3S,4R)- dichloroproline from trans-4-hydroxy-L-proline are presented. The synthetic route provides easy access to several substituted prolines and cis- hydroxylated proline esters. Various types of biological activities have been associated with these substituted prolines. The role of (-)-(3S,4R)- dichloroproline in astins A, B and C is under investigation.
