204449-09-2

Upstream product

• 188889-04-5 7-bromo-4,4-dimethyl-1-(p-tolyl)-1,2,3,4-tetrahydronaphthalen-1-ol 
• 68-12-2 N,N-dimethyl-formamide 
• 188889-06-7 6-bromo-1,1-dimethyl-4-(p-tolyl)-1,2-dihydronaphthalene 
• 166978-46-7 7-bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 204449-13-8 4-{1-[1-[5,5-Dimethyl-8-(5-methyl-thiophen-2-yl)-5,6-dihydro-naphthalen-2-yl]-meth-(E)-ylidene]-3,3-dimethoxy-propyl}-benzoic acid ethyl ester 
• 204449-10-5 4-{1-[1-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2-yl)-meth-(E)-ylidene]-3,3-dimethoxy-propyl}-benzoic acid ethyl ester 

Relevant academic research and scientific papers

A new class of potent RAR antagonists: Dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids

The synthesis and biological activity of a novel series of tricyclic retinoic acid receptor antagonists are described. These compounds bind with high affinity to the RARs and are potent antagonists of retinoid function in in vitro and in vivo systems.