204512-94-7

Usage

Uses

Used in Pharmaceutical Industry:
TETRAHYDRO-FURAN-3-YLAMINE HCL is used as a key intermediate in the synthesis of N-6 heterocyclic substituted nucleosides, which are important for the development of adenosine receptor modulators. Adenosine receptors play a significant role in various physiological processes, including cardiovascular function, neuroprotection, and immune response. By targeting these receptors, the synthesized nucleosides can potentially be used to treat a wide range of diseases and disorders.
In the synthesis process, TETRAHYDRO-FURAN-3-YLAMINE HCL can be further modified and combined with other chemical entities to create novel nucleoside analogs with improved pharmacological properties. These analogs can exhibit enhanced affinity, selectivity, and efficacy towards specific adenosine receptor subtypes, leading to the development of more effective therapeutic agents.
Furthermore, TETRAHYDRO-FURAN-3-YLAMINE HCL can also be utilized in the preparation of other bioactive molecules with potential applications in drug discovery and development. Its unique chemical structure allows for the exploration of new chemical space and the design of innovative drug candidates with improved safety and efficacy profiles.

Upstream product

• 444608-45-1 (tetrahydrofuran-3-yl)carbamic acid tert-butyl ester 
• 1070789-73-9 C₁₁H₁₅NO₃S 
• 152495-79-9 (S)-3-benzoylamino-tetrahydrofuran 

Downstream Products

• 1432908-69-4 (R)-6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-(pyridin-3-ylmethyl)-2-((tetrahydrofuran-3-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 1432910-00-3 C₂₉H₃₂ClN₇O₄ 
• 1196509-67-7 C₃₂H₃₂F₂N₄O₆ 
• 1073973-23-5 (S)-4-bromo-2-fluoro-6-((tetrahydrofuran-3-yl)amino)benzonitrile 
• 1572515-83-3 (S)-2-fluoro-5-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzoic acid 
• 1572515-41-3 (S)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzoic acid 
• 1359969-64-4 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((S)-tetrahydrofuran-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide 
• 1408148-00-4 C₂₅H₂₂ClF₄N₃O₂ 
• 939417-75-1 C₂₅H₂₂ClF₄N₃O₂ 

Relevant academic research and scientific papers

Expeditious novel routes to enantiopure 3-amino tetrahydrofuran hydrochloride

The synthesis of chemically and enantiomerically pure (S)-3-amino tetrahydrofuran hydrochloride starting from the natural amino acids, l-aspartic acid or l-methionine is described. The process involves no chromatography and can be easily carried out on a large scale. The enantiopurity of the final product was established by NMR and chiral HPLC methods.

Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives

A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.

Novel compounds

Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

N6 mono heterocyclic substituted adenosine derivatives

A substituted N 6 -oxa, thia, thioxa and azacycloalkyl substituted adenosine derivative and a method for using the composition as an A 1 heart adenosine receptor.