204513-61-1

Basic information

• Product Name: 4-BROMO-2-(PIPERIDIN-1-YL)THIAZOLE
• Synonyms: 1-(4-bromo-2-thiazolyl)Piperidine;4-BROMO-2-(PIPERIDIN-1-YL)THIAZOLE
• CAS NO: 204513-61-1
• Molecular Formula: C₈H₁₁BrN₂S
• Molecular Weight: 247.16
• Mol File: 204513-61-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-2-(PIPERIDIN-1-YL)THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(PIPERIDIN-1-YL)THIAZOLE(204513-61-1)
• EPA Substance Registry System: 4-BROMO-2-(PIPERIDIN-1-YL)THIAZOLE(204513-61-1)

Safety Data

• Hazardous Substances Data: 204513-61-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(piperidin-1-yl)thiazole is a chemical compound that contains a thiazole ring with a piperidine group attached. It is commonly utilized in the field of pharmaceuticals and agrochemicals as an intermediate for the synthesis of various compounds. This chemical is known for its potential biological activity, including antifungal and antibacterial properties. It is also used in the development of new drug candidates for a range of therapeutic purposes. Additionally, 4-Bromo-2-(piperidin-1-yl)thiazole has been studied for its potential as a building block in organic synthesis and as a reagent in chemical reactions.

Upstream product

• 110-89-4 piperidine 
• 4175-77-3 2,4-dibromo-1,3-thiazole 

Downstream Products

• 288-47-1 1,3-thiazole 

Relevant articles and documents

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner. Results of the preliminary studies are consistent with the recently described cell death mechanism ferroptosis. Studies are in progress to confirm ferroptosis as the cell death mechanism and to identify the specific molecular targets of these small molecule anticancer agents.

Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy

A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),