204527-99-1

Basic information

• Product Name: 1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester
• Synonyms: 1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester
• CAS NO: 204527-99-1
• Molecular Weight: 413.26
• Mol File: 204527-99-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester(204527-99-1)
• EPA Substance Registry System: 1-Benzyl-5-nitro-1H-imidazole-4-carboxylic acid pentafluorophenyl ester(204527-99-1)

Safety Data

• Hazardous Substances Data: 204527-99-1(Hazardous Substances Data)

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 69195-96-6 5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid 

Downstream Products

• 204528-05-2 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid methyl ester 
• 204528-06-3 2-[(5-Amino-1-benzyl-1H-imidazole-4-carbonyl)-amino]-hexanoic acid methyl ester 
• 221300-11-4 {1-[(5-Amino-1-benzyl-1H-imidazole-4-carbonyl)-amino]-2-hydroxy-ethyl}-carbamic acid benzyl ester 
• 210036-02-5 [(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-benzyloxycarbonylamino-acetic acid methyl ester 
• 210036-03-6 [(5-Amino-1-benzyl-1H-imidazole-4-carbonyl)-amino]-benzyloxycarbonylamino-acetic acid methyl ester 
• 210036-01-4 [(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-benzyloxycarbonylamino-acetic acid 
• 204528-00-7 2-[(1-Benzyl-5-nitro-1H-imidazole-4-carbonyl)-amino]-hexanoic acid 

Relevant articles and documents

Analogues of azepinomycin as inhibitors of guanase

Synthesis and biochemical screening against guanase of analogues of the naturally occurring guanase inhibitor azepinomycin (2) are reported. Compound 6-amino-5,6,7,8,-tetrahydro-4H-imidazo[4,5-e][1,4]diazepine-5,8-dione (3) was synthesized in six steps commencing with 1-benzyl-5-nitroimidazole-4- carboxylic acid (5). Compound 3 and its synthetic precursor 3-benzyl-6-(N- benzyloxycarbonyl)amino-5,6,7,8-tetrahydro-4H-imidazo[4,5-e][1,4]diazepine- 5,8-dione (12) were screened against rabbit liver guanase. Both were found to be moderate inhibitors of the enzyme with K(l)'s in the range of 10-4 M.

Pentafluorophenol: A superior reagent for condensations in heterocyclic chemistry

The use of pentafiuorophenol as a superior reagent for heterocyclic condensations, where other traditional condensing agents such as DCC and CDI failed, has been demonstrated.