204574-78-7

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 62773-87-9 N-(2-propenyl)-N-(2,2-dimethoxyethyl)amine 
• 155335-41-4 N-(2,2-dimethoxyethyl)-4-methyl-N-(2-propenyl)benzenesulfonamide 
• 530-47-2 N,N-diphenylhydrazine hydrochloride 
• 361459-74-7 4-methyl-N-(2-oxoethyl)-N-2-propen-1-ylbenzenesulfonamide 

Relevant academic research and scientific papers

Radical cyclization in heterocycle synthesis. Part 13: Sulfanyl radical addition-cyclization of oxime ethers and hydrazones connected with alkenes for synthesis of cyclic β-amino acids

A combination of sulfanyl radical addition-cyclization of the oxime ethers and hydrazones connected with alkenes and subsequent conversion of a phenylsulfanylmethyl group to a carboxyl group provides a novel method for the construction of the cyclic β-amino acids. Upon treatment with thiophenol in the presence of AIBN, the oxime ethers and hydrazones smoothly underwent sulfanyl radical addition-cyclization to give the 2-(phenylsulfanylmethyl)cycloalkylamine. This method was successfully applied to the practical synthesis of 2-aminocyclopentanecarboxylic acid and 4-amino-3-pyrrolidinecarboxylic acid.