204575-68-8Relevant academic research and scientific papers
Regioselective Ni-Catalyzed Carboxylation of Allylic and Propargylic Alcohols with Carbon Dioxide
Chen, Yue-Gang,Shuai, Bin,Ma, Cong,Zhang, Xiu-Jie,Fang, Ping,Mei, Tian-Sheng
, p. 2969 - 2972 (2017)
An efficient Ni-catalyzed reductive carboxylation of allylic alcohols with CO2 has been successfully developed, providing linear β,γ-unsaturated carboxylic acids as the sole regioisomer with generally high E/Z stereoselectivity. In addition, the carboxylic acids can be generated from propargylic alcohols via hydrogenation to give allylic alcohol intermediates, followed by carboxylation. A preliminary mechanistic investigation suggests that the hydrogenation step is made possible by a Ni hydride intermediate produced by a hydrogen atom transfer from water.
Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis
Ishikawa, Teruhiko,Nagai, Keita,Senzaki, Mami,Tatsukawa, Akiko,Saito, Seiki
, p. 2433 - 2448 (2007/10/03)
Isoxazolidines that are useful precursors for β-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile.
