204584-97-4Relevant academic research and scientific papers
Pd-catalyzed intramolecular Heck reaction for the synthesis of 2-methylbenzofurans
Zhou,Shi, Yuxing,Zhu, Xueyan,Zhang, Peng
supporting information, p. 2005 - 2008 (2019/07/03)
A new strategy for the synthesis of 2-Methylbenzofurans via the intramolecular Heck reaction has been developed. This efficient palladium-catalyzed system showed good catalytic activity. Various substituted 2-methylbenzofurans could be afforded in good to excellent yields.
P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
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Paragraph 0193-0196, (2018/04/17)
The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.
5-Quinoline derivatives having an anti-bacterial activity
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Page/Page column 16, (2010/12/31)
The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.
An elegant and unprecedented approach to 2-methylbenzofurans
Yadav, Amit K.,Singh, Biswajit K.,Singh, Nimisha,Tripathi, Rama P.
, p. 6628 - 6632 (2008/03/12)
An effective route for the synthesis of a variety of 2-methylbenzofurans is reported via DBU catalyzed dehydroiodination of easily accessible 2-iodomethyl-2,3-dihydrobenzofurans. The latter could be easily obtained by water mediated iodocyclization of allyl phenols.
Na+-glucose cotransporter inhibitors as antidiabetic agents. II. Synthesis and structure-activity relationships of 4'-dehydroxyphlorizin derivatives
Hongu, Mitsuya,Tanaka, Takashi,Funami, Nobuyuki,Saito, Kunio,Arakawa, Kenji,Matsumoto, Mamoru,Tsujihara, Kenji
, p. 22 - 33 (2007/10/03)
A novel series of 4'-dehydroxyphlorizin derivatives was synthesized and the effects of these compounds on urinary glucose excretion were evaluated in rats. There was a strict structural requirement for activity. Introduction of a small substituent or a fi
CLAISEN REARRANGEMENT OF ARYL PROPARGYL ETHERS IN POLY(ETHYLENE GLYCOL) - A REMARKABLE SUBSTITUENT AND SOLVENT EFFECT
Rao, Usha,Balasubramanian, K. K.
, p. 5023 - 5024 (2007/10/02)
The Claisen rearrangement of aryl propargyl ethers in poly(ethylene glycol)-200 at 220 o C affords products in good yields.Aryl propargyl ethers containing electron donating groups yield (2H)-benzopyrans and those containing electron withdrawing groups yield 2-methylbenzofurans.
