204587-88-2

Upstream product

• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 184714-56-5 (R)-4-benzyl-3-(2-chloroacetyl)oxazolidin-2-one 
• 122-52-1 triethyl phosphite 
• 110905-24-3 (4R)-3-(bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone 

Downstream Products

• 550334-60-6 (R)-4-benzyl-3-((2E,8E,10E)-dodeca-2,8,10-trienoyl)-oxazolidin-2-one 
• 861899-30-1 (R)-3-((S,E)-7-(4-methoxybenzyloxy)-6-methylhept-2-enoyl)-4-benzyloxazolidin-2-one 
• 861899-34-5 (E)-(S)-7-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-methyl-7-oxo-hept-5-enal 
• 861899-32-3 (R)-4-benzyl-3-((S,E)-7-hydroxy-6-methylhept-2-enoyl)oxazolidin-2-one 
• 861899-36-7 (R)-4-benzyl-3-((S,2E,7E)-8-iodo-6-methylocta-2,7-dienoyl)oxazolidin-2-one 
• 861899-38-9 (R)-3-((S,2E,7E,9E)-11-(4-methoxybenzyloxy)-6-methylundeca-2,7,9-trienoyl)-4-benzyloxazolidin-2-one 
• 184848-25-7 C₂₁H₃₁NO₃ 
• 1353545-65-9 C₂₁H₃₃NO₄Si 

Relevant academic research and scientific papers

Conjugate addition of aryl nucleophiles to α,β-unsaturated cinnamic acid derivatives containing Evans type chiral auxiliaries

Cinnamides containing oxazolidin-2-one type auxiliaries have been prepared. A novel pathway to chiral 4-aryl-6-methyl-3,4-dihydrocoumrines via the asymmetric conjugate addition of arylmagnesium bromides to these cinnamides is described.

Towards the total synthesis of marineosin A: Construction of the macrocyclic pyrrole and an advanced, functionalized spiroaminal model

Herein, we describe the enantioselective construction of the 12-membered macrocyclic pyrrole core of marineosin A in 5.1 % overall yield from (S)-propylene oxide. The route features a key Stetter reaction to install a 1,4-diketone, which is subjected to Paal-Knorr pyrrole synthesis and ring-closing metathesis to afford the macrocycle. A divergence point in the synthetic scheme also enabled access to a highly functionalized spiroaminal model system through an acid-mediated hydroxy oxo amide cyclization strategy. Copyright

Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis

Herein, we report on the identification of nonbasic, potent, and highly selective, nitrile-containing cathepsin K (Cat K) inhibitors that are built on our previously identified cyclohexanecarboxamide core structure. Subsequent to our initial investigation

A short approach to the bicyclo[4.3.0]nonane fragment of stawamycin

The bicyclo[4.3.0]nonane (C11-C21) fragment of stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (R)-(-)-3-hydroxy-2-methylpropionate. Key steps are a Pd-catalysed Stille coupling reaction

SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT

The invention relates to CGRP antagonists of general formula (I), in which A, U, V, W, X and R1 to R 3 are as defined in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures, salts, hydrates of the salts, in particular the physiologically-acceptable salts thereof with inorganic or organic acids, medicaments containing said compounds and the use and methods for production thereof.