204587-96-2Relevant articles and documents
Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from α-hydroxy-β-amino esters
Davies, Stephen G.,Fletcher, Ai M.,Frost, Aileen B.,Kennedy, Matthew S.,Roberts, Paul M.,Thomson, James E.
, p. 2139 - 2163 (2016/04/09)
A range of enantiopure 1,2,3,4-tetrahydroisoquinolines have been prepared directly from α-hydroxy-β-amino esters. Activation of the α-hydroxy group upon treatment with Tf2O and 2,6-di-tert-butyl-4-methylpyridine promotes aziridinium formation,