204589-34-4

Upstream product

• 204325-70-2 2-benzyloxy-1-(tetrahydropyran-2-yloxy)-2-(tetrahydropyran-2-yloxymethyl)-5-hexene 
• 204325-69-9 1-(tetrahydropyran-2-yloxy)-2-(tetrahydropyran-2-yloxymethyl)-5-hexen-2-ol 
• 32888-40-7 1,3-bis[(tetrahydro-2H-pyran-2-yl)oxy]-2-propanone 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 204325-71-3 2-benzyloxy-5-(tetrahydropyran-2-yloxy)-4-(tetrahydropyran-2-yloxymethyl)pentanale 

Downstream Products

• 204325-75-7 (3R,R_S)-3-benzyloxy-3,4-dihydro-3-hydroxymethyl-6-(p-toluenesulfinylmethyl)-2H-pyran 
• 204325-79-1 ((R)-Toluene-4-sulfinyl)-acetic acid (S)-2-benzyloxy-6-oxo-2-(toluene-4-sulfonyloxymethyl)-heptyl ester 
• 204325-78-0 ((R)-Toluene-4-sulfinyl)-acetic acid (E)-(S)-2-benzyloxy-6-oxo-2-(toluene-4-sulfonyloxymethyl)-hept-4-enyl ester 
• 204325-77-9 ((R)-Toluene-4-sulfinyl)-acetic acid (S)-2-benzyloxy-4-oxo-2-(toluene-4-sulfonyloxymethyl)-butyl ester 
• 204325-76-8 Toluene-4-sulfonic acid (S)-3-benzyloxy-6-((R)-toluene-4-sulfinylmethyl)-3,4-dihydro-2H-pyran-3-ylmethyl ester 
• 204325-73-5 (R_S)-5-benzyloxy-5-hydroxymethyl-2-methoxy-2-(p-toluenesulfinyl-methyl)tetrahydropyran 
• 204325-80-4 Toluene-4-sulfonic acid (S)-2-benzyloxy-2-hydroxymethyl-6-oxo-heptyl ester 
• 111650-02-3 (1S,5R)-5-methyl-1-para-toluenesulfonyloxymethyl-6,8-dioxabicyclo[3.2.1]octane 
• 204325-72-4 5-Benzyloxy-6-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-1-((R)-toluene-4-sulfinyl)-hexan-2-one 

Relevant academic research and scientific papers

1,6-Asymmetric induction utilizing Asymmetric desymmetrization by diastereoselective C-O bond fission of the 4-substituted bicyclic acetal: Application to a synthesis of (-)-frontalin

1,6-Asymmetric induction was achieved in the acid-induced diastereoselective acetal cleavage reaction of a 4-substituted bicyclic acetal 8 bearing a chiral sulfinyl group. On treatment with titanium tetrachloride and 2,6-disubstituted pyridine bases, 8 gave a synthetically versatile 3,3-disubstituted dihydropyran derivative 9a with moderate diastereoselectivity. The utility of this chiral synthon was successfully demonstrated by a formal synthesis of (-)-frontalin.