204589-80-0

Basic information

• Product Name: Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate
• Synonyms: Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate;3-Azetidinepropanoic acid, 1-(4-fluorophenyl)-2-oxo-4-[4-(phenylMethoxy)phenyl]-, Methyl ester, (3R,4S)- (REACH);3-Azetidinepropanoic acid, 1-(4-fluorophenyl)-2-oxo-4-[4-(phenylMethoxy)phenyl]-, Methyl ester, (3R,4S)-;1-(4-fluorophenyl)-2-oxo-4-[4-(phenylMethoxy)phenyl]-,Methyl ester,(3R,4S)-3-Azetidinepropanoic acid;Methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate;Trans-methyl-3-(((3-[2-oxo-4(benzyloxyphenyl)-1-(4-fluorophenyl)-azetidinone])propionate;Ezetimibe Impurity 18
• CAS NO: 204589-80-0
• Molecular Formula: C₂₆H₂₄FNO₄
• Molecular Weight: 433.47
• EINECS: 1308068-626-2
• Mol File: 204589-80-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 628.309 °C at 760 mmHg
• Flash Point: 333.789 °C
• Appearance: /
• Density: 1.238
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate(204589-80-0)
• EPA Substance Registry System: Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate(204589-80-0)

Safety Data

• Hazardous Substances Data: 204589-80-0(Hazardous Substances Data)

Usage

Uses

Methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate is a reagent for the synthesis of antihypercholesterolemia drug ezetimibe.

InChI:InChI=1/C26H24FNO4/c1-31-24(29)16-15-23-25(28(26(23)30)21-11-9-20(27)10-12-21)19-7-13-22(14-8-19)32-17-18-5-3-2-4-6-18/h2-14,23,25H,15-17H2,1H3/t23-,25-/m1/s1

Upstream product

• 204589-68-4 Ezetimibe Related Impurity 7 
• 204589-58-2 EzetiMibe Dehydoxy IMpurity 
• 204588-77-2 2,2-DIMETHYL-BUT-3-YNOIC ACID BENZYL ESTER 
• 204587-97-3 tert-Butyl-(2S,3S)-3-amino-2-hydroxy-3-phenylpropanoate 
• 204587-95-1 TERT-BUTYL (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOATE,97% 
• 204587-92-8 tert-Butyl-(2S,3S)-3-amino-2-hydroxybutanoate 
• 204587-91-7 TERT-BUTYL (2R,3R)-3-AMINO-2-HYDROXYBUTANOATE,97% 
• 204587-90-6 TERT-BUTYL (3S)-3-AMINO-4-HEXENOATE, 97 
• 204587-89-3 TERT-BUTYL (3R)-3-AMINO-4-HEXENOATE, 97 
• 204587-86-0 (R)-(+)-N-ALLYL-1-PHENYLETHYLAMINE HYDROCHLORIDE, 95 
• 204587-83-7 Benzoic acid, 4-(2-methyl-3-oxopropyl)-, methyl ester, (R)- (9CI) 
• 20458-78-0 4(1H)-Isoquinolinone, 2,3-dihydro-2-Methyl-, hydrochloride 
• 204587-79-1 Benzoic acid, 4-(2-methyl-3-oxopropyl)-, methyl ester, (S)- (9CI) 
• 204587-57-5 2-Cyclopenten-1-ol,4-[(methylthio)methoxy]-,cis-(9CI) 

Downstream Products

• 204589-82-2 (3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid 
• 20458-99-5 2,6-DIETHYLPHENYL ISOCYANATE 
• 20459-06-7 3-Phenylisothiazol-4-ol acetate 
• 204592-23-4 4-(2-AMINO-2-METHYLPROPYL) PHENOL ACETIC ACID 
• 204592-29-0 Methanamine, 1-(2-methoxyphenoxy)- (9CI) 
• 204592-97-2 6-[4-[2-[3-(9H-Carbazol-4-yloxy)-2(S)-hydroxypropylamino]-2-methylpropyl]phenoxy]pyridine-3-carboxamide hydrochloride 
• 20459-48-7 diethyl (1-aminobutyl)phosphonate 
• 20459-51-2 diethyl (1-amino-3-methylbutyl)phosphonate 
• 20459-52-3 diethyl (1-amino-2-methylbutyl)phosphonate 
• 20459-60-3 (1-AMINO-3-METHYLBUTYL)PHOSPHONIC ACID 
• 20459-61-4 (1-AMINO-2-METHYLBUTYL)PHOSPHONIC ACID 
• 20459-66-9 bis(chloromethyl)phosphinothioic chloride 
• 20459-74-9 ethyl bis(2,2,2-trichloro-1-hydroxyethyl)phosphinate 
• 20459-84-1 chloro(methyl)naphthalen-1-yl(phenyl)germane 

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