20461-04-5 Usage
Function
Herbicide and algaecide
Mode of action
Inhibits photosynthesis by blocking electron transport chain in chloroplasts and disrupting ATP synthesis
Solubility
Low in water
Environmental behavior
Binds strongly to soil particles, making it persistent in the environment
Ecological concerns
Potential for long-term accumulation and toxicity to aquatic organisms
Impact on non-target species
Raises concerns about its effect on ecosystems and non-target species
Regulation
Regulated in many countries
Use restrictions
Subject to specific guidelines and restrictions to mitigate environmental impact
Check Digit Verification of cas no
The CAS Registry Mumber 20461-04-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,6 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20461-04:
(7*2)+(6*0)+(5*4)+(4*6)+(3*1)+(2*0)+(1*4)=65
65 % 10 = 5
So 20461-04-5 is a valid CAS Registry Number.
20461-04-5Relevant articles and documents
Antischistosomal activity of N,N′-arylurea analogs against Schistosoma japonicum
Yao, Houzong,Liu, Fengyou,Chen, Jinglei,Li, Yan,Cui, Jinhao,Qiao, Chunhua
supporting information, p. 1386 - 1390 (2016/02/19)
Although the antischistosomal activities of N,N′-arylurea analogs were reported, systematic structure-activity relationships have not been conducted. In this Letter, we reported the design, synthesis and evaluation of 45 N,N′-arylurea analogs. Among these prepared compounds, 13 compounds were urea linker modified and 32 were N,N′-arylurea derivatives. The activity evaluation revealed 12 analogs exhibited IC50 values lower than 22.6 μM, and 7 of them had IC50 less than 10 μM against the juvenile Schistosoma japonicum in vitro. Their worm killing potency was even higher against adult worm. Unfortunately, low to moderate worm burden reduction of 0-33.4% was recorded after administration of a single oral dose of 200 mg/kg or 400 mg/kg to mice harboring S. japonicum.
