20461-07-8Relevant academic research and scientific papers
Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives
-
, (2008/06/13)
The present invention is concerned with the use of carbonylamino derivatives of the formula wherein R signifies lower alkyl, lower alkenyl, lower alkinyl, cycloalkyl, lower alkoxy or CF3; R1signifies hydrogen or lower alkyl; R2and R3signify, independently from each other, hydrogen, halogen or nitro; Y signifies CH or N; n is 0-6; m is 0-2; as well as with their pharmaceutically acceptable salts for the treatment of diseases, which relate to metabotropic glutamate receptor antagonists and/or agonists.
The conversion of carboxylic acids into amides via NCS/triphenylphosphine
Froyen
, p. 959 - 968 (2007/10/02)
Amides can be generated in very high yields under mild conditions from the corresponding carboxylic acid and amine in the presence of equivalent amounts of triphenylphosphine and N-halosuccinimides, e.g., NCS or NBS.
