204634-59-3Relevant academic research and scientific papers
BIPHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND PREPARATION METHOD THEREOF
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Paragraph 0166-0167; 0244-0245, (2014/08/19)
Provided are biphenyl derivatives exhibiting activity towards central nervous system diseases by acting on the 5-HT7 receptor, pharmaceutically acceptable salts thereof, a method for preparing the compounds and pharmaceutical compositions inclu
Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists
Kim, Jeeyeon,Kim, Youngjae,Tae, Jinsung,Yeom, Miyoung,Moon, Bongjin,Huang, Xi-Ping,Roth, Bryan L.,Lee, Kangho,Rhim, Hyewhon,Choo,Chong, Youhoon,Keum, Gyochang,Nam, Ghilsoo,Choo, Hyunah
, p. 1855 - 1864 (2014/01/06)
The 5-HT7 receptor (5-HT7R) is a promising therapeutic target for the treatment of depression and neuropathic pain. The 5- HT7R antagonist SB-269970 exhibited antidepressant-like activity, whereas systemic administration of the 5-HT
