204649-66-1 Usage
General Description
Z-Leu-Leu-Tyr-a-keto aldehyde is a chemical compound derived from the amino acids leucine, tyrosine, and an aldehyde group. It is a potent inhibitor of the proteasome, an enzyme complex involved in the degradation of proteins, making it a valuable tool for studying protein degradation pathways and potential therapeutic targets. Z-Leu-Leu-Tyr-a-keto aldehyde has been shown to regulate apoptosis in cancer cells by inhibiting the proteasome, leading to the accumulation of ubiquitinated proteins and triggering cell death. Additionally, Z-Leu-Leu-Tyr-a-keto aldehyde has been investigated for its potential anti-inflammatory properties, making it a promising candidate for further study in the fields of oncology and immunology.
Check Digit Verification of cas no
The CAS Registry Mumber 204649-66-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,6,4 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 204649-66:
(8*2)+(7*0)+(6*4)+(5*6)+(4*4)+(3*9)+(2*6)+(1*6)=131
131 % 10 = 1
So 204649-66-1 is a valid CAS Registry Number.
204649-66-1Relevant articles and documents
Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehyde (glyoxals)
Lynas, John F.,Harriott, Patrick,Healy, Adrienne,McKervey, M. Anthony,Walker, Brian
, p. 373 - 378 (2007/10/03)
A series of peptidyl α-keto aldehydes (glyoxals) have been synthesised as putative inhibitors of the chymotryptic-like activity of proteasome. The most potent peptides, Cbz-Leu-Leu-Tyr-COCHO and Bz-Leu-Leu-Leu-COCHO, function as slow-binding reversible inhibitors, exhibiting final K(i) values of approximately 3.0 nM. These are among the lowest values so far reported for (tri)peptide-based aldehyde-releated inhibitors.
