204650-26-0

Basic information

• Product Name: [4-(4-Ethyl-3,5-dimethoxy-phenyl)-1-methyl-2-oxo-pyrrolidin-3-yl]-acetic acid tert-butyl ester
• CAS NO: 204650-26-0
• Molecular Weight: 377.481
• Mol File: 204650-26-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(4-Ethyl-3,5-dimethoxy-phenyl)-1-methyl-2-oxo-pyrrolidin-3-yl]-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-Ethyl-3,5-dimethoxy-phenyl)-1-methyl-2-oxo-pyrrolidin-3-yl]-acetic acid tert-butyl ester(204650-26-0)
• EPA Substance Registry System: [4-(4-Ethyl-3,5-dimethoxy-phenyl)-1-methyl-2-oxo-pyrrolidin-3-yl]-acetic acid tert-butyl ester(204650-26-0)

Safety Data

• Hazardous Substances Data: 204650-26-0(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 204650-25-9 4-(4-ethyl-3,5-dimethoxy-phenyl)-1-methyl-pyrrolidin-2-one 
• 204650-06-6 3-Cyano-3-(4-ethyl-3,5-dimethoxy-phenyl)-propionic acid ethyl ester 
• 204650-24-8 4-(4-ethyl-3,5-dimethoxy-phenyl)-pyrrolidin-2-one 
• 204650-04-4 (4-Ethyl-3,5-dimethoxy-phenyl)-acetonitrile 
• 204650-48-6 5-Chloromethyl-2-ethyl-1,3-dimethoxy-benzene 
• 203579-18-4 4-ethyl-3,5-dimethoxybenzyl alcohol 

Downstream Products

• 204650-27-1 cis-7-ethyl-6-hydroxy-8-methoxy-2-methyl-1,2,3,3a,4,9b-hexahydro-5H-benzo[e]isoindol-5-one 

Relevant articles and documents

Syntheses of O-Methylasparvenone-derived Serotonin-receptor Antagonists

Based on O-methylasparvenone (1), a N-free 5HT2C antagonist with moderate affinity (pKi = 6.7), derivatives bearing dimethylamino (7), (dimethylamino)methyl (17, 18, 21, and 22), and aminomethyl substituents (26) in place of the benzylic OH group of 1 as well as pyrrolidine- (33) and piperidine-fused derivatives (29, 43, and 45) were synthesized.In contrast to the lead structure 1, these new ligands were active in vivo in the rat.The tricycles 33 and 45 display high affinities for the 5HT2C receptor (pKi = 8).