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204656-20-2

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Product FOB Price Min.Order Supply Ability Supplier
LIRAGLUTIDE
Cas No: 204656-20-2
No Data No Data 1-100 Kilogram/Month Afine Chemicals Limited Contact Supplier
Liraglutide peptide API custom manufacturing
Cas No: 204656-20-2
No Data 1 Gram 20 Kilogram/Year Suzhou Tianma Pharma Group Tianji Bio-pharmaceutical Co.,Ltd. Contact Supplier
Liraglutide
Cas No: 204656-20-2
No Data 1 Kilogram 1000 Kilogram/Year HANWAYS CHEMPHARM CO.,LIMITED Contact Supplier
Liraglutide
Cas No: 204656-20-2
No Data 1 Gram 100 Kilogram/Week Senova Technology Company Limited Contact Supplier
factory supply High quality Liraglutide 204656-20-2 in stock good supplier
Cas No: 204656-20-2
USD $ 1.0-1.0 / Gram 1 Gram 1 Kilogram/Month SICHUAN TONGSHENG AMINOACID CO.LTD Contact Supplier
Peptide - Liraglutide, 95%
Cas No: 204656-20-2
USD $ 1500.0-1500.0 / Gram 1 Gram 20 Gram/Week Hangzhou Go Top Peptide Biotech Co.,Ltd. Contact Supplier
Liraglutide CAS NO 204656-20-2
Cas No: 204656-20-2
USD $ 100.0-200.0 / Gram 1 Gram 10 Kilogram/Month Zhejiang Peptites Biotech Co.,Ltd Contact Supplier
Liraglutide,CAS 204656-20-2
Cas No: 204656-20-2
No Data 1 Gram 1 Kilogram/Month GUANGZHOU MEDCAN PHARMATECH LTD Contact Supplier
Liraglutide
Cas No: 204656-20-2
No Data 1 Kilogram 500 Kilogram/Month Huarong Industrial Group Ltd. Contact Supplier
High purity Various Specifications liraglutide CAS:204656-20-2
Cas No: 204656-20-2
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier

204656-20-2 Usage

Adverse reaction

Liraglutide treatment process is very low in the incidence of hypoglycemia. Gastrointestinal discomfort is the most common adverse reactions in the liraglutide treatment, slowly increasing the liraglutide dosage can reduce the proportion of dose related nausea. Gastrointestinal discomfort commonly appear at the first week in liraglutide treatment, diarrhea and nausea occur most frequently, most of them are short, slight or tolerable, and are related with liraglutide dose.

Medicine for treating type 2 diabetes mellitus

As a new long-acting GLP-1 analogues liraglutide, GLP-1 has 97% sequence homology, human GLP-1 can bind to and activate GLP-1 receptor. GLP-1 receptor as the target of natural GLP-1, GLP-1 is a kind of endogenous incretin hormone, can promote islet βcell proliferation and differentiation, protective and improved the function of islet β cells. And liraglutide is simple and convenient, once a day can provide 24 h blood glucose control, and low risk of hypoglycemia, is expected to become a new drug for treatment of type 2 diabetes.
Liraglutide is the first and currently the only GLP-1 (pancreatic glucagon like peptide-1) analogues, which has been widely used in Europe, the United States and Japan. Pancreatic glucagon like peptide-1 is a kind of incretin insulin when oral intake of nutrients, pancreatic glucagon like peptide-1 can promote insulin secret, but human GLP-1 can be dipeptide based peptidase 4 (DPP-4) rapidly degraded. Liraglutide is GLP-1 receptor full agonist, 97% of the amino acid sequence is the same molecule of human GLP-1. People said that there are two differences between two molecules. First of all, C16 fatty acids in the 26th by glutamate connection to lysine acid. Secondly, in the 34 lysine acid is replaced by arginine, to ensure that C16 side chain can only be combined in the 26. Fatty acid side chains can liraglutide in night's blood and albumin reversible combination, so that the action time of liraglutide extended and enhanced degradation of the DPP-4 enzyme to resist and fatty acid side chains can also enable liraglutide molecular selfing in injection site into heptamers, thus delaying the subcutaneous attract, the function of the time for up to 24 hours, daily injections of a and in injection for any length of time has nothing to do with meal.
Liraglutide is type 2 diabetes therapy and revolutionized the field of drug , Applicable to use metformin or sulfonylureas maximum tolerated dose still poorly controlled blood sugar after treatment in patients with type 2 diabetes, glucose concentration dependent manner to regulate blood sugar, protect B cells directly, increase insulin secretion and decrease a cell in inappropriate glucagon secretion, by increasing satiety and reducing caloric intake and body weight reduction, lower systolic blood pressure (SBP), earlier used better. Liraglutide peptide with metformin or a sulfonylurea drug combination has a significant effect, less adverse reaction.
The above information is edited by the Chemicalbook Hanya.

Definition

ChEBI: A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve gly emic control in adults with type 2 diabetes mellitus.
InChI:InChI=1/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-128(223)193-112(59-64-132(227)228)148(244)180-68-41-40-50-111(154(250)199-116(62-67-135(233)234)155(251)204-120(73-100-44-33-31-34-45-100)160(256)214-140(93(11)19-2)168(264)192-97(15)146(242)201-122(76-103-79-183-108-49-39-38-48-106(103)108)158(254)203-118(72-90(5)6)159(255)212-138(91(7)8)166(262)200-110(52-43-70-182-172(177)178)150(246)184-81-129(224)194-109(51-42-69-181-171(175)176)149(245)187-84-137(237)238)196-144(240)95(13)189-143(239)94(12)191-153(249)115(58-63-127(174)222)195-130(225)82-185-152(248)114(61-66-134(231)232)198-156(252)117(71-89(3)4)202-157(253)119(75-102-54-56-105(221)57-55-102)205-163(259)124(85-216)208-165(261)126(87-218)209-167(263)139(92(9)10)213-162(258)123(78-136(235)236)206-164(260)125(86-217)210-170(266)142(99(17)220)215-161(257)121(74-101-46-35-32-36-47-101)207-169(265)141(98(16)219)211-131(226)83-186-151(247)113(60-65-133(229)230)197-145(241)96(14)190-147(243)107(173)77-104-80-179-88-188-104/h31-36,38-39,44-49,5

204656-20-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name liraglutide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:204656-20-2 SDS

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