20469-89-0Relevant articles and documents
Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice
Dutra, Luiz A.,Lacerda, Mariella G.,Destro Inácio, Maiara,Martins, Johnny W.L.,Lopes Silva, Ana C.,Bento da Silva, Patricia,Chorilli, Marlus,Amato, Angélica A.,Baviera, Amanda M.,Passarelli, Marisa,Guido, Rafael V.C.,Dos Santos, Jean L.
supporting information, (2022/01/26)
Peroxisome proliferator-activated receptors are promising therapeutic targets for metabolic diseases, including obesity, diabetes, and dyslipidemia. This study describes the design, synthesis and pharmacological evaluation of stilbene-based compounds as d
Method for synthesizing netarsudil intermediate
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Paragraph 0067-0073; 0088-0093; 0109-0115, (2019/11/20)
The invention relates to a method for synthesizing a netarsudil intermediate that is 6-aminoisoquinoline. The method includes (1) dissolving 2-bromo-2-methylpropionic acid; (2) adding oxalyl chloride,and then reacting the mixture; (3) after the reaction is completed, pouring the reaction solution into aqueous ammonia, stirring the mixture, performing filtration and drying a product. The method utilizes conventional and easily available chemical materials, and has characteristics of mild reactions, a short route and a high yield.
Synthesis method for alectinib hydrochloride intermediate
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Paragraph 0036; 0044; 0050; 0051, (2017/10/12)
The invention discloses a synthesis method for an alectinib hydrochloride intermediate. The synthesis method includes the following steps: 1) with 2-bromo-2-methylpropionic acid as an initial raw material, adding thionyl chloride to perform a chlorination reaction to obtain a compound (I); 2) adding ethylbenzene to the compound (I) and adding anhydrous aluminum trichloride as a catalyst to perform a substitution reaction to obtain a compound (II); 3) dissolving the compound (II) in an organic solvent, adding HC(OMe)3 and a catalyst ZnCl2, performing heat reflux until a rearrangement reaction is completely finished to obtain a compound (III); 4) dissolving the compound (III) in an organic solvent, adding iodine and iodic acid to perform a catalytic reaction to generate a compound (IV); and 5) under alkaline condition, hydrolyzing the compound (IV) to produce the target product, alectinib hydrochloride intermediate. The synthesis method is simple in operations, has high yield and is lower in cost.