204690-22-2

Basic information

• Product Name: (Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide
• Synonyms: (Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide
• CAS NO: 204690-22-2
• Molecular Weight: 348.423
• Mol File: 204690-22-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide(204690-22-2)
• EPA Substance Registry System: (Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide(204690-22-2)

Safety Data

• Hazardous Substances Data: 204690-22-2(Hazardous Substances Data)

Upstream product

• 23060-14-2 diethyl 2-mercaptosuccinate 
• 51838-02-9 2-cyano-N-(2-phenylethyl)ethanamide 

Downstream Products

• 235423-15-1 (2Z,5Z)-(5-Ethoxycarbonylmethylidene-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide 
• 728929-68-8 2-[5-(2-hydroxy-ethyl)-4-oxo-thiazolidin-2-ylidene]-N-phenethyl-acetamide 
• 285133-48-4 (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide 

Relevant articles and documents

Configurational isomerization of push-pull thiazolidinone derivatives controlled by intermolecular and intramolecular RAHB: 1H NMR dynamic investigation of concentration and temperature effects

1H NMR spectroscopy was used to investigate hydrogen bonding in the structurally related (Z)- and (E)-5-substituted-2-alkylidene-4-oxothiazolidines in polar and apolar solvents. The equilibrated mixtures of these typical push-pull alkenes consi

Regioselective synthesis and spectral characterization of ethyl (Z)- and (E)-2-alkylidene-4-oxothiazolidine-5-acetate derivatives. Solvent effects on the Z-E isomerization

The title compounds containing an exocyclic double bond of exclusively the Z-configuration were prepared in anhydrous ethanol by the regio-selective base catalyzed reaction of diethyl 2-mercaptobutanedioate with nitrile precursors possessing an acidic α-hydrogen. The 1H NMR data indicating the presence of both geometrical isomers in primarily nonpolar media favoring the E-form are presented in terms of the solvent influence on intra- and intermolecular H-bonding and stereochemical outcome of the reaction.