204694-99-5

Basic information

• Product Name: S-(4-cyclohexyl)benzyl-L-cysteine
• Synonyms: S-(4-cyclohexyl)benzyl-L-cysteine
• CAS NO: 204694-99-5
• Molecular Weight: 293.43
• Mol File: 204694-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: S-(4-cyclohexyl)benzyl-L-cysteine(CAS DataBase Reference)
• NIST Chemistry Reference: S-(4-cyclohexyl)benzyl-L-cysteine(204694-99-5)
• EPA Substance Registry System: S-(4-cyclohexyl)benzyl-L-cysteine(204694-99-5)

Safety Data

• Hazardous Substances Data: 204694-99-5(Hazardous Substances Data)

Upstream product

• 4463-31-4 4-cyclohexylbenzyl chloride 
• 52-89-1 l-cysteine hydrochloride 

Downstream Products

• 204693-89-0 N-[(2S)-3-benzoylthio-2-methylpropionyl]-S-(4-cyclohexyl)benzyl-L-cysteine 

Relevant articles and documents

Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors

We studied synthetic modifications of N-mercaptoacylamino acid derivatives to develop a new class of leukotriene A4 (LTA4) hydrolase inhibitors. S-(4-Dimethylamino)benzyl-l-cysteine derivative 2a (SA6541) showed inhibitory activity against LTA4 hydrolase (IC50, 270 nM) and selectivity over other metallopeptidases except angiotensin-converting enzyme (ACE, IC50, 520 nM). Modification at the para-substituent of the phenyl ring of compound 2a improved LTA4 hydrolase inhibitory activity as well as selectivity over ACE. Finally, we obtained S-(4-cyclohexyl)benzy-l-cysteine derivatives 11l and 16i as potent and selective LTA4 hydrolase inhibitors.