204695-36-3Relevant academic research and scientific papers
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1
Han, Xiaojun,Civiello, Rita L.,Conway, Charles M.,Cook, Deborah A.,Davis, Carl D.,MacCi, Robert,Pin, Sokhom S.,Ren, Shelly X.,Schartman, Richard,Signor, Laura J.,Thalody, George,Widmann, Kimberly A.,Xu, Cen,Chaturvedula, Prasad V.,MacOr, John E.,Dubowchik, Gene M.
, p. 4723 - 4727 (2012/08/13)
We have systematically studied the effects of varying the central unnatural amino acid moiety on CGRP receptor antagonist potency and CYP inhibition in a series of ureidoamides. In this Letter, we report the discovery of compound 23, a potent CGRP recepto
