204772-85-0Relevant articles and documents
Application of CoMFA and CoMSIA 3D-QSAR and Docking Studies in Optimization of Mercaptobenzenesulfonamides as HIV-1 Integrase Inhibitors
Kuo, Chih-Ling,Assefa, Haregewein,Kamath, Shantaram,Brzozowski, Zdzialaw,Slawinski, Jaroslaw,Saczewski, Franciszek,Buolamwini, John K.,Neamati, Nouri
, p. 385 - 399 (2004)
An essential step in the HIV life cycle is integration of the viral DNA into the host chromosome. This step is catalyzed by a 32-kDa viral enzyme HIV integrase (IN). HIV-1 IN is an important and validated target, and the drugs that selectively inhibit thi
Syntheses of some new 4-chloro-2-mercapto-N(4H-1,2,4-triazol-3-YL) benzenesulphonamides with potential anticancer or anti-HIV activity
Slawinski, JarosLaw
, p. 461 - 466 (2007/10/03)
4-Chloro-2-mercapto-5-R1-N-(4-R2-4H-1,2,4-triazol-3-yl)benzenesulphonamide [VIII-XIV] were prepared from the corresponding 4-chloro-3-(R2-amino)-5-R1-1,1-dioxo-1,4,2-benzodithiazines [I-VII] then compd. [VIII-X]