204803-26-9

Basic information

• Product Name: 1H-Imidazole,1-(cyclopropylcarbonyl)-(9CI)
• Synonyms: 1H-Imidazole,1-(cyclopropylcarbonyl)-(9CI);1-cyclopropanecarbonyl-1H-iMidazole
• CAS NO: 204803-26-9
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15122
• Product Categories: AMIDE;AMINETERTIARY
• Mol File: 204803-26-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 282.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 3.57±0.10(Predicted)
• CAS DataBase Reference: 1H-Imidazole,1-(cyclopropylcarbonyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole,1-(cyclopropylcarbonyl)-(9CI)(204803-26-9)
• EPA Substance Registry System: 1H-Imidazole,1-(cyclopropylcarbonyl)-(9CI)(204803-26-9)

Safety Data

• Hazardous Substances Data: 204803-26-9(Hazardous Substances Data)

Usage

Structure

A five-membered imidazole ring with two nitrogen atoms and a cyclopropylcarbonyl group attached to one of the nitrogen atoms.

Biological and pharmaceutical applications

Ability to interact with enzymes and receptors in the body.

Potential use in synthesis

Can be used in the synthesis of pharmaceutical drugs or as a building block in organic chemistry reactions.

Versatility

Diverse potential applications in the fields of chemistry and biology.

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 1759-53-1 cyclopropanecarboxylic acid 
• 288-32-4 1H-imidazole 
• 4023-34-1 cyclopropanecarboxylic acid chloride 

Downstream Products

• 4333-56-6 cyclopropyl bromide 
• 14113-94-1 2-phenyl-1-cyclopropylethan-1-one 
• 32249-35-7 methyl 3-cyclopropyl-3-oxopropanoate 
• 134302-07-1 tert-butyl 3-cyclopropyl-3-oxopropanoate 

Relevant articles and documents

Combined Photoredox and Carbene Catalysis for the Synthesis of α-Amino Ketones from Carboxylic Acids

α-Amino ketone moieties are present in many pharmacologically active molecules, but their synthesis is challenging. Herein, we report a mild, operationally simple method for direct acylation of α-amino C(sp3)-H bonds from carboxylic acids via the merger of carbene and photoredox catalysis. Specifically, cross-coupling reactions between a wide range of carboxylic acids, a class of feedstock chemicals, and readily available N-alkyl anilines by means of single-electron N-heterocyclic carbene catalysis combined with photocatalysis provided access to structurally diverse α-amino ketones. The method features a broad substrate scope and is compatible with a wide array of functional groups. To demonstrate the potential applications of the method, we subjected one of the α-amino ketone products to further transformations.

A new method for synthesizing ring-propyl bromide (by machine translation)

The invention relates to a new method for synthesizing ring-propyl bromide of: the ring n-propyl formate reaction with carbonyl diimidazole generating cyclopropanecarboxylic acyl imidazole, the intermediate is then mixed together with trichloro curafume, maintain 10 °C to 140 °C slowly dropping under the conditions of the free radical bromination reaction of deacidifying cyclopropyl bromine thick obtained after, through simple atmospheric distillation to obtain the purity 99% product of the above. The mild reaction conditions, conventional reagent used is cheap and easy to obtain, by avoiding the use of oxidized mercury squeezing, is suitable for industrial production. (by machine translation)

THIAZOLYL-DIHYDRO-INDAZOLE

Disclosed are compounds of general formula (I), wherein the groups R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-indazoles and the use thereof as pharmaceutical compositions.