20481-15-6Relevant articles and documents
Synthesis and characterization of new 1H-pyrazolo[3,4-b]pyridine phosphoramidate derivatives
Pedrosa, Leandro F.,De Macedo, William P.,Furtado, Antonia C.R.,Guedes, Guilherme P.,Borges, Julio C.,Resende, Jackson A.L.C.,Vaz, Maria G.F.,Bernardino, Alice M.R.,De Souza, Marcos C.
, p. 38 - 50 (2014/04/17)
Twelve new 1H-pyrazolo[3,4-b]pyridine phosphoramidate derivatives were synthesized under mild conditions by nucleophilic aromatic substitution reaction of aminoalkylphosphoramidates over 4-Cl substituted pyrazolo[3,4-b]pyridine in good yields. The new com
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist
Rimland, Joseph,Dunne, Angela,Hunjan, Suchete S.,Sasse, Rosemary,Uings, Iain,Montanari, Dino,Caivano, Matilde,Shah, Poonam,Standing, David,Gray, David,Brown, David,Cairns, William,Trump, Ryan,Smith, Paul W.,Bertheleme, Nicolas,D'Alessandro, Pier,Gul, Sheraz,Vimal, Mythily,Smith, David N.,Watson, Stephen P.
scheme or table, p. 2340 - 2343 (2010/08/22)
The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure-activity relationships and the process of optimisation of an initial HTS hit are also described.
PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
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Page/Page column 77, (2008/12/07)
The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formura 1: can be useful in the treatment, prevention, inhibitio