204842-15-9

Basic information

• Product Name: 3-Pyridineacetaldehyde,alpha-methyl-(9CI)
• Synonyms: 3-Pyridineacetaldehyde,alpha-methyl-(9CI)
• CAS NO: 204842-15-9
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16316
• Product Categories: PYRIDINE
• Mol File: 204842-15-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridineacetaldehyde,alpha-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridineacetaldehyde,alpha-methyl-(9CI)(204842-15-9)
• EPA Substance Registry System: 3-Pyridineacetaldehyde,alpha-methyl-(9CI)(204842-15-9)

Safety Data

• Hazardous Substances Data: 204842-15-9(Hazardous Substances Data)

Upstream product

• 1121-55-7 3-vinylpyridine 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

Chemoselectivity in the rhodium-catalyzed hydroformylation of 4-vinylpyridine: Crucial role of phosphine ligand in promoting carbonylation instead of hydrogenation

Hydroformylation of 4-vinylpyridine (4VP) in benzene with Rh4(CO)12/PMe2Ph or Rh4CO12 as catalytic precursor shows completely different chemoselectivity, carbonylation product (branched aldehyde) largely prevailing with the first catalyst, hydrogenation product 4-ethylpyridine (4EP) with the second one. Different phosphines and P/Rh ratios were also used, and a comparison with 3-vinylpyridine (3VP) under the same experimental conditions was made too. In all the experiments 3VP exclusively gives aldehidic products. In the case of 4VP, hydrogenation prevails on carbonylation at low P/Rh ratio (0.5), while for higher values more than 80% of carbonylation product is obtained. The strong electron-donor phosphine ligand changes the polarization of the carbon-rhodium bond making this carbon suitable for the migratory insertion process and hence determining the acyl-metal intermediate formation precursor of the aldehyde.