204847-08-5

Basic information

• Product Name: 2-(5-METHYL-FURAN-2-YL)-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: 2-(5-METHYL-FURAN-2-YL)-QUINOLINE-4-CARBOXYLIC ACID;TIMTEC-BB SBB000923;2-(5-methyl-2-furyl)quinoline-4-carboxylic acid
• CAS NO: 204847-08-5
• Molecular Formula: C15H11NO3
• Molecular Weight: 253.25
• Mol File: 204847-08-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(5-METHYL-FURAN-2-YL)-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-METHYL-FURAN-2-YL)-QUINOLINE-4-CARBOXYLIC ACID(204847-08-5)
• EPA Substance Registry System: 2-(5-METHYL-FURAN-2-YL)-QUINOLINE-4-CARBOXYLIC ACID(204847-08-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 204847-08-5(Hazardous Substances Data)

Usage

Molecular weight

265.262 g/mol
The mass of one mole of the compound, calculated from its molecular formula.

Heterocyclic compound

Contains both carbon and non-carbon atoms (such as nitrogen and oxygen) in its ring structure.

Quinoline ring

A bicyclic aromatic compound consisting of a benzene ring fused with a pyridine ring.

Furan ring

A heterocyclic compound consisting of a five-membered ring with one oxygen atom and four carbon atoms.

Carboxylic acid group

A functional group consisting of a carbonyl group (C=O) and a hydroxyl group (OH) attached to the same carbon atom.

Pharmaceutical applications

Potential use in the development of new drugs due to its ability to interact with biological targets.

Enzyme inhibition

The compound may act as an inhibitor of specific enzymes, which could be useful in treating enzyme-related diseases or conditions.

Receptor ligand

The compound may bind to specific receptors in the body, potentially modulating their activity and producing therapeutic effects.

Biological activities

May exhibit properties such as anti-inflammatory or antimicrobial effects, which could be useful in the development of new medications.

Further research and development

Ongoing studies and development of this compound may lead to the discovery of new drugs for various medical conditions.

Upstream product

• 1193-79-9 2-acetyl-5-methylfuran 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1207098-57-4 N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide 

Relevant articles and documents

2-furanyl-quinoline-4-formamide compound and application thereof

The invention discloses a 2-furanyl-quinoline-4-formamide compound and application thereof, and the structural formula of the 2-furanyl-quinoline-4-formamide compound is shown as a formula (4) in thespecification, wherein R1 is selected from H, halogen or

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity

SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Structure-activity relationship analyses led to the identific

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries

High-throughput screening (HTS) was employed to discover APOBEC3G inhibitors, and multiple 2-furylquinolines (e.g., 1) were found. Dose-response assays with 1 from the HTS sample, as well as commercial material, yielded similar confirmatory results. Interestingly, freshly synthesized and DMSO-solubilized 1 was inactive. Repeated screening of the DMSO aliquot of synthesized 1 revealed increasing APOBEC3G inhibitory activity with age, suggesting that 1 decomposes into an active inhibitor. Laboratory aging of 1 followed by analysis revealed that 1 undergoes oxidative decomposition in air, resulting from a [4 + 2] cycloaddition between the furan of 1 and 1O2. The resulting endoperoxide then undergoes additional transformations, highlighted by Baeyer-Villager rearrangements, to deliver lactam, carboxylic acid, and aldehyde products. The endoperoxide also undergoes hydrolytic opening followed by further transformations to a bis-enone. Eight structurally related analogues from HTS libraries were similarly reactive. This study constitutes a cautionary tale to validate 2-furylquinolines for structure and stability prior to chemical optimization campaigns.