204850-14-6

Basic information

• Product Name: 1-BroMo-4-isopropyl-2-nitrobenzene
• Synonyms: 1-BroMo-4-isopropyl-2-nitrobenzene
• CAS NO: 204850-14-6
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.0852
• Mol File: 204850-14-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 263.3±28.0 °C(Predicted)
• Appearance: /
• Density: 1.456±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-BroMo-4-isopropyl-2-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BroMo-4-isopropyl-2-nitrobenzene(204850-14-6)
• EPA Substance Registry System: 1-BroMo-4-isopropyl-2-nitrobenzene(204850-14-6)

Safety Data

• Hazardous Substances Data: 204850-14-6(Hazardous Substances Data)

Upstream product

• 586-61-8 4-iso-propylbromobenzene 

Downstream Products

• 943780-25-4 tert-butyl (S)-4-(2-(7-isopropylquinazolin-4-ylamino)-4-(1-phenylethylcarbamoyl)phenylthio)phenylcarbamate 
• 943780-27-6 (R)-4-(4-aminophenylthio)-N-(2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylquinazolin-4-ylamino)benzamide 
• 943780-22-1 (S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide 
• 943780-29-8 4-(4-(tert-butoxycarbonylamino)phenylthio)-3-(7-isopropylquinazolin-4-ylamino)benzoic acid 
• 943780-28-7 methyl 4-(4-(tert-butoxycarbonylamino)phenylthio)-3-(7-isopropylquinazolin-4-ylamino)benzoate 
• 943780-24-3 4-chloro-7-isopropylquinazoline 
• 35480-95-6 4-isopropyl-2-nitro-benzoic acid 
• 774165-27-4 2-amino-4-isopropylbenzoic acid 
• 204850-15-7 4-isopropyl-2-nitrobenzonitrile 

Relevant articles and documents

BIARYL LIGANDS FOR TRANSITION METAL-CATALYZED REACTIONS

In one embodiment, the present application discloses ligands of the formula A, wherein the variables are as described herein, and methods for using the ligands in cross-coupling reactions in organic and polar media:

2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease

A series of 2-amino-4H-3,1-benzoxazin-4-ones have been synthesized and evaluated as inhibitors of the complement enzyme C1r. C1r is a serine protease at the beginning of the complement cascade, and complement activation by β-amyloid may represent a major contributing pathway to the neuropathology of Alzheimer's disease. Compounds such as 7-chloro-2-[(2- iodophenyl)amino]benz[d][1,3]oxazin-4-one (32) and 7-methyl-2-[(2- iodophenyl)amino]benz[d][1,3]oxazin-4-one (37) show improved potency compared to the reference compound FUT-175. Many of these active compounds also possess increased selectivity for C1r compared to trypsin and enhanced hydrolytic stability relative to 2-(2-iodophenyl)-4H-3,1-benzoxazin-4-one (1).