204907-85-7

Upstream product

• 917237-75-3 C₂₅H₃₁N₃O₅ 

Downstream Products

• 204907-80-2 ((S)-1-{(S)-1-[(S)-1-((4R,5R)-5-{(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-2-phenyl-ethyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Method for synthesis of C2-symmetric diamino diol mediated by titanium complexes

A method for synthesis of C2-symmetric diamino diol mediated by titanium complexes is provided. A substituted-L-phenylalaninal undergoes pinacol coupling to yield the corresponding C2-symmetric (1S,2R,3R,4S)-1,4-diamino 2,3-diol in the presence of Cp2TiCl2/ZnCl2 and zinc metal, mediated in good yield and highly selective. This titanium-catalyzed reaction yields diaminodiol, offering a convenient alternative method to the synthesis of C2-symmetric peptidic protease inhibitors. Consequently, the method allows to synthesize TL-3 via titanium complex in moderate yield.

Anti-coronavirus compounds

A method of treating coronavirus infection. The method includes administering to a subject suffering from or being at risk of suffering from such infection an effective amount of a compound of formula (I). Each variable in this formula is defined in the specification.