204974-81-2Relevant academic research and scientific papers
Mass spectrometry of heterocyclic compounds: Benzo[b]pyrazolo[3,4-b]-1,6-naphthyridines
Khakwani, Samia,Aslam, Samina,Shahi, Mehrzadi Noureen,Rolim Bernardino, Alice M.,Khan, Misbahul Ain
, p. 2385 - 2387 (2016/10/19)
The mass spectra of a number of benzo[b]pyrazolo[3,4-b]-1,6-naphthyridines are presented. The fragmentation involves elimination of CO molecule followed by other fragments, such as halogen (Cl, Br) or halogen acids (HCl, HBr) and HCN, etc.
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series
Bernardino, Alice M.R.,Castro, Helena C.,Frugulhetti, Izabel C.P.P.,Loureiro, Natalia I.V.,Azevedo, Alexandre R.,Pinheiro, Luiz C.S.,Souza, Thiago M.L.,Giongo, Viveca,Passamani, Fabiana,Magalhaes, Uiaran O.,Albuquerque, Magaly G.,Cabral, Lucio M.,Rodrigues, Carlos R.
, p. 313 - 321 (2008/04/05)
Herpes Simplex Virus (HSV) infections are among the most common human diseases. In this work, we assess the structural features and electronic properties of a series of ten 1-hydroxyacridone derivatives (1a-j) recently described as a new class of non-nucl
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives
Leal, Bruno,Afonso, Ilidio F.,Rodrigues, Carlos R.,Abreu, Paula A.,Garrett, Rafael,Pinheiro, Luiz Carlos S.,Azevedo, Alexandre R.,Borges, Julio C.,Vegi, Percilene F.,Santos, Claudio C.C.,da Silveira, Francisco C.A.,Cabral, Lucio M.,Frugulhetti, Izabel C.P.P.,Bernardino, Alice M.R.,Santos, Dilvani O.,Castro, Helena C.
scheme or table, p. 8196 - 8204 (2009/04/11)
Antibacterial resistance is a complex problem that contributes to health and economic losses worldwide. The Staphylococcus epidermidis is an important nosocomial pathogen that affects immunocompromised patients or those with indwelling devices. Currently,
Synthesis and antiviral activity of new 4-(phenylamino)/4-[(methylpyridin- 2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids derivatives
Bernardino, Alice Maria Rolim,De Azevedo, Alexandre Reis,Pinheiro, Luiz Carlos Da Silva,Borges, Julio Cesar,Carvalho, Vinicius Lucio,Miranda, Milene Dias,De Meneses, Marcelo Damiao Ferreira,Nascimento, Marcelo,Ferreira, Davis,Rebello, Moacyr Alcoforado,Silva, Viveca Antonia Giongo Galvao Da,De Frugulhetti, Izabel Christina Palmer Paixao
, p. 352 - 369 (2008/12/21)
The synthesis of new 4-(phenylamino)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4- carboxylic acid (3a-l) derivatives and the new 4-[(methylpyridin-2-yl)amino]-1- phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (5a-c) derivatives was achieved with an efficient synthetic route. Ethyl 4-chloro-1-phenyl-1H- pyrazolo[3,4-b]pyridine-5-carboxylate (1) on fusion with appropriate substituted anilines or aminopicolines gave the required new ethyl 4-(phenylamino)-1- phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylates (2a-l) (52-82%) or new ethyl 4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5- carboxylates (4a-c) (50-60%), respectively. Subsequent hydrolysis of the esters afforded the corresponding carboxylic acids (3a-l) (86-93%) and (5a-c) in high yield (80-93%). Inhibitory effects of 4-(phenylamino)/4-[(methylpyridin-2-yl) amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acids. Derivatives on Herpes simplex virus type 1 (HSV-1), Mayaro virus (MAY) and vesicular stomatitis virus (VSV) were investigated. Compounds 2d, 3f, 3a, and 3c exhibited antiviral activity against HSV-1, MAY, and VSV virus with EC50 values of 6.8, 2.2, 4.8, 0.52, 2.5, and 1.0. None of these compounds showed toxicity for Vero cells.
New tetracyclic heteroaromatic ring system 3H-benzo[b]pyrazolo[3, 4-h]-1, 6-naphthyridines
De Azevedo, Alexandre Reis,Frugulhetti, Izabel C.P.P.,Khan, Misbahul Ain,Khakwani, Samia,Bernardino, Alice M. Rolim
, p. 47 - 54 (2007/10/03)
Various derivatives of the tetracyclic ring system 3H-Benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine were prepared from 4-anilino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acids by intramolecular cyclization employing phophoryl chloride. 1H NMR spectra of the various derivatives were recorder.
