204985-91-1Relevant academic research and scientific papers
Tetrakis(Trimethylsilyl) ethenylidenebisphosphonate: A mild and useful reagent for the synthesis of substituted 2-aminoethylidene-1,1-bisphosphonic acids
Shevchuk, Michael V.,Romanenko, Vadim D.,Kukhar, Valery P.
, p. 799 - 801 (2011)
Tetrakis(trimethylsilyl) ethenylidenebisphosphonate is proposed as a substrate in the preparations of N-substituted 2-aminoethylidene-1,1- bisphosphonic acids. The method provides an extremely mild protocol for the synthesis of these compounds and is compatible with a wide range of functional groups. Copyright Taylor & Francis Group, LLC.
Tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate: A mild and convenient Michael acceptor for the synthesis of 2-aminoethylidene-1,1- bisphosphonic acids and their potassium salts
Shevchuk, Michael V.,Sotiropoulos, Jean-Marc,Miqueu, Karinne,Romanenko, Vadim D.,Kukhar, Valery P.
supporting information; experimental part, p. 1370 - 1374 (2011/08/03)
A straightforward synthesis of highly functionalized 2-aminoethylidene-1,1- bisphosphonic acids via the Michael addition of amines to easily available tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate, H2C=C[P(O) (OTMS)2]
