205059-24-1

Basic information

• Product Name: 1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE
• Synonyms: 4-PIPERIDIN-4-YL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE;1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE >98%;tert-butyl 4-(piperidin-4-yl)piperazine-1-carboxylate;1-Boc-4-(4-piperidinyl)-piperazine;2-Methylpropan-2-yl 4-(piperidin-4-yl)piperazine-1-carboxylate;1-Piperazinecarboxylicacid, 4-(4-piperidinyl)-, 1,1-diMethylethyl ester
• CAS NO: 205059-24-1
• Molecular Formula: C₁₄H₂₇N₃O₂
• Molecular Weight: 269.38
• Product Categories: pharmacetical;Piperidine
• Mol File: 205059-24-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 70-74°C
• Boiling Point: 362.9°C at 760 mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.069
• Vapor Pressure: 1.87E-05mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.27±0.10(Predicted)
• CAS DataBase Reference: 1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE(205059-24-1)
• EPA Substance Registry System: 1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE(205059-24-1)

Safety Data

• Hazardous Substances Data: 205059-24-1(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(piperidin-4-yl)-piperazine is a chemical compound used in the pharmaceutical industry as a building block for the synthesis of various drugs and research compounds. With a full systematic name of tert-butyl 4-(4-piperidyl)piperazine-1-carboxylate, this compound is often used as a precursor for the production of potential therapeutic agents that target specific biological pathways. It is known for its potential pharmacological effects, including its ability to modify neurotransmitter levels and receptor activity in the central nervous system. Additionally, it has been studied for its potential antipsychotic and analgesic properties. Overall, 1-BOC-4-(piperidin-4-yl)-piperazine is an important chemical in the field of medicinal chemistry, with potential applications in drug discovery and development.

InChI:InChI=1/C14H27N3O2/c1-14(2,3)19-13(18)17-10-8-16(9-11-17)12-4-6-15-7-5-12/h12,15H,4-11H2,1-3H3

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 926904-28-1 tert-butyl 4-(1-((benzyloxy)carbonyl)piperidin-4-yl)piperazine-1-carboxylate 
• 939983-24-1 4-(1-Fmoc-piperidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 205059-23-0 4-[1-(phenylmethyl)-4-piperidinyl]-1-(1,1-dimethylethoxycarbonyl)-piperazine 

Downstream Products

• 926904-28-1 tert-butyl 4-(1-((benzyloxy)carbonyl)piperidin-4-yl)piperazine-1-carboxylate 

Relevant articles and documents

CDK4/6 INHIBITOR

Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers.

PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS

The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

NEW COMPOUNDS

The present invention encompassescompounds of general formula (1) wherein R1 to R4 , X and n are defined as in claim 1, which are suitable for the treatment of ailments characterised byexcessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.