205109-97-3

Upstream product

• 198482-51-8 6-O-allylerythromycin A 
• 412333-77-8 C₅₅H₁₀₄N₂O₁₄Si₂ 
• 412333-79-0 6-O-allylerythromycin A 9(Z)-oxime 
• 205109-94-0 (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-7-Allyloxy-6-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-4,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 
• 205109-95-1 Benzoic acid (2S,3R,4S,6R)-2-((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-7-allyloxy-14-ethyl-4,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 381222-32-8 Benzoic acid (2S,3R,4S,6R)-4-dimethylamino-2-[(3R,5R,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-2,4,10-trioxo-7-((E)-3-phenyl-allyloxy)-oxacyclotetradec-6-yloxy]-6-methyl-tetrahydro-pyran-3-yl ester 
• 1053248-32-0 Benzoic acid (2S,3R,4S,6R)-2-{(3R,5R,6R,7R,9R,11R,12R,13S,14R)-7-[(E)-3-(4-chloro-phenyl)-allyloxy]-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-2,4,10-trioxo-oxacyclotetradec-6-yloxy}-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester 
• 205110-40-3 Imidazole-1-carboxylic acid (E)-(2R,3S,7R,9R,10R,11R,13R)-9-allyloxy-10-((2S,3R,4S,6R)-3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,5,7,9,11,13-hexamethyl-6,12,14-trioxo-oxacyclotetradec-4-en-3-yl ester 
• 205110-19-6 6-O-[3-(3-quinolyl)-2-propen-1-yl]-3-descladinose-3-oxo-2'-O-benzoyl erythromycin A 

Relevant academic research and scientific papers

6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY

PROBLEM TO BE SOLVED: To provide 6-O-substituted ketolides with antibacterial activity, having acid stability and enhanced activity toward gram negative bacteria and macrolide resistant gram positive bacteria. SOLUTION: This invention provides 6-O-substituted erythromycin ketolide derivatives such as formula (II) and compositions comprising the compounds. [Y and Z together form a group X; X is ketone, hydroxyimino or the like; or, one of Y and Z is H and the other is hydrogen, hydroxy or the like; Ra is H, hydroxy; Rc is H or a hydroxy protective group; R is a substituted methyl group]. COPYRIGHT: (C)2015,JPOandINPIT

Novel Erythromycin Derivatives with aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

A novel series of erythromycin derivatives has been discovered with potent activity against key respiratory pathogens, including those resistant to erythromycin. These compounds are characterized by having an aryl group tethered to the C-6 position of the