205116-75-2

Usage

Uses

Used in Organic Synthesis:
2-(2,9,9-TriMethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidine is utilized as a synthetic intermediate for the development of novel organic compounds. Its unique structure and properties make it a valuable building block in the synthesis of complex organic molecules, potentially leading to the creation of new pharmaceuticals, agrochemicals, or specialty chemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(2,9,9-TriMethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidine is employed as a potential candidate for drug discovery. Its distinctive molecular architecture may offer new avenues for the design of therapeutic agents, particularly those targeting specific biological pathways or receptors. Further investigation into its reactivity and interactions with biological systems is necessary to fully realize its potential in this area.
Used in Research and Development:
2-(2,9,9-TriMethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidine serves as a subject of interest in academic and industrial research settings. Its unique structure and properties make it an intriguing compound for studying the fundamental aspects of chemistry, such as reactivity, selectivity, and stability. Additionally, it may inspire the development of new synthetic methods or strategies to access complex molecular architectures.
Used in Material Science:
Although not explicitly mentioned in the provided materials, the unique structure of 2-(2,9,9-TriMethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-pyrrolidine may also find applications in material science. Its potential use in the development of new materials with specific properties, such as high thermal stability, chemical resistance, or unique electronic characteristics, could be explored through further research and development efforts.

Upstream product

• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 

Downstream Products

• 149716-72-3 (1S,2S,3R,5S)-pinanediol L-proline boronate hydrochloride 
• 149716-72-3 L-proline boric acid-(1S,2S,3R,5S)-(+)-2,3-pinanediol ester hydrochloride 
• 149716-72-3 (RS)-proline boronic acid-(1S,2S,3R,5S)-(+)-2,3-pinanediol ester hydrochloride 

Relevant academic research and scientific papers

Proline boric acid compound and preparation method and applications thereof

The invention provides a compound whose structure is shown as a formula (I) or a salt thereof. The compound is a proline boric acid proteasome inhibitor compound, and has good proteasome inhibitory activity and excellent druggability. The structural formula of the compound is shown as the formula (I).

Synthesis and biological activity of peptide proline-boronic acids as proteasome inhibitors

On the basis of the application of proline-boronic acid as pharmacophore in the kinase inhibitors and our previous research results, using proline-boronic acid as warhead, two series of peptide proline-boronic acids, dipeptide proline-boronic acids (I) and tripeptide proline-boronic acids (II), were designed and synthesized. All the synthesized compounds were first evaluated for their biological activity against MGC803 cell, and then, the best compound II-7 was selected to test its anti-tumor spectrum on six human tumor cell lines and proteasome inhibition against three subunits. The results indicated that series II have much better biological activities than series I. The compound II-7 exhibited not only excellent biological activities with IC50 values of nM level in both cell and proteasome models, but also much better subunit selectivity. Thus, proline-boronic acid as warhead is reasonable in the design of proteasome inhibitors.

A (-)-sparteine-directed highly enantioselective synthesis of boroproline. Solid- and solution-state structure and properties

(Chemical Equation Presented) A two-step, direct asymmetric synthesis of the trifluoroacetate ammonium salt of boroproline is reported. (-)-Sparteine-mediated lithiation of N-Boc-pyrrolidine afforded N-Boc-aminoboronic acid in good yield and enantioselectivity as determined by HPLC (pinanediol ester). Deprotection using TFA yielded the ammonium salt; full characterization data are presented, and the structure in aqueous solution and the occurrence of a B-N species are discussed.