205117-49-3

Upstream product

• 146557-69-9 1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine 
• 204326-30-7 Benzoic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(2-methylphosphinoyl-ethyl)-tetrahydro-furan-3-yl ester 
• 204326-29-4 Benzoic acid (2R,3S,5R)-2-{2-[(1,1-diethoxy-ethyl)-methyl-phosphinoyl]-ethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 167369-83-7 1-((2R,4R,5R)-5-{2-[(1,1-Diethoxy-ethyl)-methyl-phosphinoyl]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 205117-50-6 C₄₆H₅₅N₄O₁₀PSi 

Relevant academic research and scientific papers

The utilization of secondary phosphine oxide synthons for the preparation of novel tertiary phosphine oxide modified DNA

Novel tertiary phosphine oxides are described which act as masked secondary phosphine oxides. The protection of the reactive P-H bond allows generation of a carbanion alpha to phosphorus and subsequent alkylation with an oxetane. The free P-H can then be liberated with anhydrous acid. This functionality can then be further alkylated to generate novel tertiary phosphine oxide backbone modified DNA.