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205127-44-2

3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine is a complex organic chemical compound with the molecular formula C11H9F3N4. It is a derivative of pyrazole, a five-membered heterocyclic compound containing three nitrogen atoms. The structure of this compound features a methyl group at the 3-position, a trifluoromethyl group at the 4-position of the phenyl ring, and an amino group at the 5-position of the pyrazole ring. 3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine is of interest in the field of medicinal chemistry, as it may exhibit potential biological activities and could be a candidate for further development as a pharmaceutical agent. Its synthesis and properties are subjects of ongoing research, with potential applications in the development of new drugs targeting various diseases and conditions.

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  • 205127-44-2 Structure

  • Basic information

    1. Product Name: 3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine
    2. Synonyms: 3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine
    3. CAS NO:205127-44-2
    4. Molecular Formula: C11H10F3N3
    5. Molecular Weight: 241.2124096
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 205127-44-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine(205127-44-2)
    11. EPA Substance Registry System: 3-Methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine(205127-44-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 205127-44-2(Hazardous Substances Data)

205127-44-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 205127-44-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,1,2 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 205127-44:
(8*2)+(7*0)+(6*5)+(5*1)+(4*2)+(3*7)+(2*4)+(1*4)=92
92 % 10 = 2
So 205127-44-2 is a valid CAS Registry Number.

205127-44-2Downstream Products

205127-44-2Relevant articles and documents

Oxidative Ring-Opening of 1H-Pyrazol-5-amines and Its Application in Constructing Pyrazolo–Pyrrolo–Pyrazine Scaffolds by Domino Cyclization

Bao, Xiaoguang,Fu, Rui,Gao, Ke,Jin, Feng,Pan, Lei,Zhou, Shaofang

supporting information, p. 2956 - 2961 (2020/05/16)

Herein, an oxidative ring-opening of 1H-pyrazol-5-amines to form 3-diazenylacrylonitrile derivatives under mild and transition-metal-free conditions is described. In addition, the nucleophilic addition of deprotonated 1H-pyrrole-2-carbaldehydes to the vinyl moiety of the yielded 3-diazenylacrylonitriles could trigger domino cyclization to afford the 3H-pyrazolo[3,4-e]pyrrolo[1,2-a]pyrazine derivatives. Computational studies suggest that the oxidation of 1H-pyrazol-5-amines in the presence of PhIO is through the formation of a hydroxylamine intermediate followed by elimination of H2O to result in the ring-opening product. The detailed domino cyclization pathway leading to the pyrazolo–pyrrolo–pyrazine scaffolds is revealed.

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists

Patnaik, Samarjit,Basu, Dipanwita,Southall, Noel,Dehdashti, Seameen,Wan, Kanny K.,Zheng, Wei,Ferrer, Marc,Taylor, Mercedes,Engel, Daniel A.,Marugan, Juan Jose

supporting information, p. 1113 - 1119 (2019/03/08)

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.

NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

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Page/Page column 15, (2013/02/28)

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine alpha7 receptor.

PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM

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Page/Page column 34-35, (2013/03/26)

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said com- pounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

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