205191-26-0Relevant academic research and scientific papers
4-Methyl-3,4-dihydrospiro[cycloheptane-1′,2(1H)-quinoline]and 4-Methyl-3,4-dihydrospiro[cyclooctane-1′,2(1H)-quinoline]. Synthesis of Derivatives and Chemical Transformations
Palma, Alirio,Rozo, Wilson,Stashenko, Elena,Molina, Daniel,Kouznetsov, Vladimir
, p. 183 - 188 (1998)
New derivatives of 3,4-dihydrospiro[cycloalkane-1′,2(1H)-quinolines] were obtained from cycloheptanone and cyclooctanone via facile three steps hetero spiro annulation process. Their nitro derivatives were prepared through electrophilic substitution reactions.
In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers
Vargas M., Leonor Y.,Castelli, Maria V.,Kouznetsov, Vladimir V.,Urbina G., Juan M.,Lopez, Silvia N.,Sortino, Maximiliano,Enriz, Ricardo D.,Ribas, Juan C.,Zacchino, Susana
, p. 1531 - 1550 (2007/10/03)
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.
