20529-24-2

Upstream product

• 440117-85-1 C₂₂H₂₅N₃O₃ 
• 16015-71-7 4-(3-methoxyphenyl)piperazine 
• 536-90-3 m-Anisidine 
• 25253-05-8 3-(4-(3-methoxyphenyl)-1-piperazinyl)propionitrile 

Downstream Products

• 129011-05-8 2-Methoxy-N-{3-[4-(3-methoxy-phenyl)-piperazin-1-yl]-propyl}-5-sulfamoyl-benzamide 
• 1240266-77-6 C₂₇H₃₆N₄O₂*ClH 

Relevant academic research and scientific papers

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

POTENTIAL NEUROLEPTICS OF THE ORTHOPRAMIDE SERIES; SYNTHESIS OF N-(3-(TERT.AMINO)PROPYL)-5-SULFAMOYL-2-METHOXYBENZAMIDES

Heating ethyl 5-sulfamoyl-2-methoxybenzoate with a series of twelve 3-(tert.amino)propylamines (IIIa-IIIl) afforded the title compounds IIa-IIl which were transformed to salts and subjected to pharmacological screening as potential neuroleptics of the sulpiride series.Only compounds IId (hydrogen oxalate, VUFB-15 453) and IIg (methanesulfonate, VUFB-15 397) showed indications of the desired psychotropic activity.