20529-69-5

Upstream product

• 613-46-7 2-naphthalenecarbonitrile 
• 19315-13-0 methyl(phenyl)phosphineoxide 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 580-13-2 2-bromonaphthalene 
• 7301-81-7 ethyl (S)-methyl(phenyl)phosphinate 
• 644-97-3 Dichlorophenylphosphine 
• 5761-97-7 methyl(phenyl)phosphinic chloride 
• 6389-79-3 methyl methylphenylphosphinate 
• 15849-86-2 methyl(phenyl)chlorophosphine 
• 20684-97-3 chloro(diisopropylamino)(phenyl)phosphine 
• 29415-54-1 methyl-(2-naphthyl)(phenyl)phosphine 
• 381717-34-6 C₃₃H₄₆NO₃PSSi 
• 917-54-4 methyllithium 
• 21232-92-8 (-)(S)-β-Naphthyl-phenyl-phosphinsaeure-(-)-menthylester 

Downstream Products

• 381716-99-0 (S)-(+)-methyl(naphthalen-2-yl)(phenyl)phosphane 

Relevant academic research and scientific papers

A facile and practical preparation ofP-chiral phosphine oxides

A practical and cost-effective synthetic method ofP-chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during s

Nickel-catalyzed C-P cross-coupling by C-CN bond cleavage

Prosperous coupling: A nickel-catalyzed C-P cross-coupling reaction with Me3SiPPh2 by carbon-cyano bond cleavage has been developed. This method is characterized by its simplicity and wide application to the synthesis of various monophosphorus and P,N bidentate ligands (see scheme).

Kinetic resolution of racemic ferrocenylphosphine compounds by enantioselective oxidation using cyclic selenoxides having a chiral ligand

Cyclic selenoxides having an optically active binaphthyl skeleton work as the reagents for enantioselective oxidation of phosphines to the corresponding phosphine oxides. Treatment of a racemic 2-oxazolin-2-ylferrocenylphosphine with one of the selenoxides in carbon tetrachloride in the presence of phenol affords the corresponding phosphine oxide together with the unreacted starting phosphine, both with moderate enantioselectivities (the phosphine oxide, up to 13% ee; the phosphine, up to 29% ee).

A simple resolution procedure using the Staudinger reaction for the preparation of P-stereogenic phosphine oxides

The resolution of a variety of (±)-P-stereogenic phosphines is achieved by exploiting the Staudinger reaction of a (±)-phosphine with enantiopure (1S,2R)-O-(tert-butyldimethylsilyl)isobornyl-10-sulfonyl azide. The resulting mixtures of diastereomeric phosphinimines are generally separable by fractional crystallization or flash chromatography. Subsequent acid-catalyzed hydrolysis provides the corresponding optically pure phosphine oxides in high yields.