205318-00-9Relevant academic research and scientific papers
Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity
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, (2008/06/13)
Disclosed are compounds of formula (I) wherein W is CH or N; R is (mono- or di cabocyclic or heterocyclic aryl)-lower alkyl; R1is hydrogen or lower alkyl; R2and R3are hydrogen, lower alkyl, lower alkoxy-lower alkyl or aryl
Carboxy-substituted cinnamides: A novel series of potent, orally active LTB4 receptor antagonists
Greenspan, Paul D.,Fujimoto, Roger A.,Marshall, Paul J.,Raychaudhuri, Anil,Lipson, Kenneth E.,Zhou, Huanghai,Doti, Robert A.,Coppa, David E.,Zhu, Lijuan,Pelletier, Roberta,Uziel-Fusi, Susan,Jackson, Robert H.,Chin, Michael H.,Kotyuk, Bernard L.,Fitt, John J.
, p. 164 - 172 (2007/10/03)
A series of carboxy-substituted cinnamides were investigated as antagonists of the human cell surface leukotriene B4 (LTB4) receptor. Binding was determined through measurement of [3H]-LTB4 displacement from hum
