205371-31-9Relevant academic research and scientific papers
New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies
Sundriyal, Sandeep,Viswanad, Bhoomi,Ramarao, Poduri,Chakraborti, Asit K.,Bharatam, Prasad V.
scheme or table, p. 4959 - 4962 (2009/05/30)
A new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand bin
Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARγ activators
Kumar, Rakesh,Mittal, Amit,Ramachandran, Uma
, p. 4613 - 4618 (2008/03/11)
The design and synthesis of novel series of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (pyrimidone) derivatives that are high affinity ligands for peroxisome proliferators activated receptor γ have been reported as a potential substitu
Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists
Cai, Zhefeng,Feng, Jun,Guo, Yanshen,Li, Pingping,Shen, Zhufang,Chu, Fengming,Guo, Zongru
, p. 866 - 874 (2007/10/03)
A series of azaindole-α-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure-activity relationship was developed for PPARα/γ dual agonism. One of the synthesized compound 7a was identified as a potent
Novel euglycemic and hypolipidemic agents
Lohray, Braj B.,Bhushan, Vidya,Rao, Bheema P.,Madhavan, Gurram R.,Murali, Nagabelli,Rao, Krowidi N.,Reddy, Ananth K.,Rajesh, Bagepalli M.,Reddy, Pamulapati G.,Chakrabarti, Ranjan,Vikramadithyan, Reeba K.,Rajagopalan, Ramanujam,Mamidi, Rao N.V.S.,Jajoo, Hemant K.,Subramaniam, Swaminathan
, p. 1619 - 1630 (2007/10/03)
A series of [[(heterocyclyl)ethoxy]benzyl]-2,4-thiazolidinediones have been synthesized by the condensation of corresponding aldehyde 1 and 2,4- thiazolidinedione followed by hydrogenation. Both unsaturated thiazolidinedione 2 and its saturated counterpar
