205371-48-8Relevant academic research and scientific papers
Novel indole containing thiazolidinedione derivatives as potent euglycemic and hypolipidaemic agents
Lohray, Braj B.,Bhushan,Rao, P. Bheema,Madhavan,Murali,Rao, K. Narasimha,Reddy, K. Anantha,Rajesh,Reddy, P. Ganpathy,Chakrabarti,Rajagopalan
, p. 785 - 788 (1997)
Several thiazolidinediones having indol as heterocyclic moiety have been synthesized and evaluated for euglycemic properties. A few of them have been found to be superior to troglitazone.
New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies
Sundriyal, Sandeep,Viswanad, Bhoomi,Ramarao, Poduri,Chakraborti, Asit K.,Bharatam, Prasad V.
scheme or table, p. 4959 - 4962 (2009/05/30)
A new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand bin
Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARγ activators
Kumar, Rakesh,Mittal, Amit,Ramachandran, Uma
, p. 4613 - 4618 (2008/03/11)
The design and synthesis of novel series of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (pyrimidone) derivatives that are high affinity ligands for peroxisome proliferators activated receptor γ have been reported as a potential substitu
Novel euglycemic and hypolipidemic agents
Lohray, Braj B.,Bhushan, Vidya,Rao, Bheema P.,Madhavan, Gurram R.,Murali, Nagabelli,Rao, Krowidi N.,Reddy, Ananth K.,Rajesh, Bagepalli M.,Reddy, Pamulapati G.,Chakrabarti, Ranjan,Vikramadithyan, Reeba K.,Rajagopalan, Ramanujam,Mamidi, Rao N.V.S.,Jajoo, Hemant K.,Subramaniam, Swaminathan
, p. 1619 - 1630 (2007/10/03)
A series of [[(heterocyclyl)ethoxy]benzyl]-2,4-thiazolidinediones have been synthesized by the condensation of corresponding aldehyde 1 and 2,4- thiazolidinedione followed by hydrogenation. Both unsaturated thiazolidinedione 2 and its saturated counterpar
