205380-85-4Relevant academic research and scientific papers
HIV replication inhibitors
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, (2008/06/13)
This invention concerns HIV replication inhibitors of formula the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, provided that when Q is halo then Z is N; or when Q is polyh
RATE-CONTROLLED PARTICLES
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, (2008/06/13)
Rate-controlled particles, comprising compounds of the formula as a solid dispersion.
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues
Ludovici, Donald W.,Kavash, Robert W.,Kukla, Michael J.,Ho, Chih Y.,Ye, Hong,De Corte, Bart L.,Andries, Koen,De Bethune, Marie-Pierre,Azijn, Hilde,Pauwels, Rudi,Moereels, Henry E.L.,Heeres, Jan,Koymans, Lucien M.H.,De Jonge, Marc R.,Van Aken, Koen J.A.,Daeyaert, Frederik F.D.,J. Lewi, Paul,Das, Kalyan,Arnold, Edward,Janssen, Paul A.J.
, p. 2229 - 2234 (2007/10/03)
A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV struct
Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU)
Ludovici, Donald W.,Kukla, Michael J.,Grous, Philip G.,Krishnan, Suma,Andries, Koen,De Bethune, Marie-Pierre,Azijn, Hilde,Pauwels, Rudi,De Clercq, Erik,Arnold, Edward,Janssen, Paul A.J.
, p. 2225 - 2228 (2007/10/03)
Stemming from work on a previous clinical candidate, loviride, and other α-APA derivatives, a new series of potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been synthesized. The ITU analogues, which contain a unique diarylated imidoyl thiourea, are very active in inhibiting both wild-type and clinically important mutant strains of HIV-1.
