2054-75-3Relevant academic research and scientific papers
A short synthesis of apoyohimbines via a sulfolene based intramolecular Diels-Alder reaction
Leonard, John,Appleton, Diana,Fearnley, Stephen P.
, p. 1071 - 1074 (1994)
Allo-apoyohimbine and apoyohimbine have been synthesized in a short sequence of high yielding, stereoselective steps. The key step is an intramolecular Diels-Alder reaction, which under kinetically controlled conditions provides the required hexahydroisoquinoline D/E-ring intermediate, but under thermodynamic control gives a hydroisoindole system, via a conjugated diene.
