205443-19-2Relevant articles and documents
Enzymatic resolution of methyl N-alkyl-azetidine-2-carboxylates by Candida antarctica lipase-mediated ammoniolysis
Starmans, Wim A. J.,Doppen, Roy G.,Thijs, Lambertus,Zwanenburg, Binne
, p. 429 - 435 (1998)
A facile method for the synthesis of optically active azetidine-2- carboxylic acid derivatives is presented Racemic N-alkylated azetidine esters are resolved by lipase from Candida antarctica in an ammoniolysis reaction, and both the S-amide and the R-ester are obtained with excellent stereoselectivity.